Which values in the CBC and differential are abnormal, if any?

CLB 462 – Hematology Spring 2022

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Table 1 Table 2

Figure 1: Peripheral blood smear (Wright-Giemsa stain, X100)

CBC RBC 5.25 x 1012/L HGB 15.4 g/dL HCT 46.1 % MCV 87.9 fL MCH 29.3 pg MCHC 33.4 g/dL RDW 12.2 Platelets 333 x 109/L

Differential WBC: 12.9 x 109/L

Neutrophil 24% Lymphocytes 73% Monocytes 0% Eosinophils 3% Basophils 0%

Mini Case Study Assignment #1 Patient History Ryan is a 23-year old, athletic male. Over the past week, he noted increasing fatigue, sore throat, earaches, headaches, and episodic fever and chills. These symptoms have prevented Ryan from being able to run his customary 25 miles per week. He decides to see his doctor, Dr. Kalamazoo, at the end of the week.

Physical Examination Upon examining Ryan, Dr. Kalamazoo notices that his throat and tonsils are erythematous, and his cervical lymph nodes are swollen. Dr. Kalamazoo immediately orders a complete blood count (CBC) and differential. Remember that the differential is an addition to the CBC that quantifies each TYPE of white blood cell and expresses it as a percentage.

CBC and Differential Results and Microscopic Examination of Peripheral Blood Smear

CLB 462 – Hematology Spring 2022

Questions: 1. Which values in the CBC and differential are abnormal, if any? (2 points)

2. How would you describe the erythrocytes with regard to color and size? Use appropriate

terms. (2 points)

3. Is there any platelet satellitism? Why? (1 point)

4. Identify the three large, light blue cells on the peripheral blood smear. What are they, and which cellular characteristics led you to your answer? (3 points)

Additional Information During physical examination, Ryan mentions to Dr. Kalamazoo that his roommate has been ill with infectious mononucleosis for the past two weeks. Dr. Kalamazoo asks him if they ever drink from the same glass or bottle, and Ryan replies that they sometimes do.

5. Why would Dr. Kalamazoo ask this question? Is there a relationship between infectious mononucleosis and Ryan’s clinical signs and symptoms? (2 points)

• Mini Case Study Assignment #1
• Physical Examination
• CBC and Differential Results and Microscopic Examination of Peripheral Blood Smear
• Additional Information